Salutations!

As the cost of "Sick"care skyrockets so to do the cost associated with every aspect of the sick care industry (insurance premiums, co-pays, pharmaceutical drugs, sick leave, etc.). The time to act and take care of ourselves while jealously guarding our health has come. We can no longer afford to hand over our health or our wealth to others and hope to live happy, productive lives. The goal of this blog is to wade through some of the more mundane as well as a few sensational health issues that affect us today and how to get over them.







Showing posts with label Enzymes. Show all posts
Showing posts with label Enzymes. Show all posts

Wednesday, March 5, 2014

The Story of Cholesterol: Energy, CoQ10 and Statins



We have reached the point where the discussion turns to the practical side of things. Once the thinking is done we must put into practice what we have learned. Right off the top the need for a disclaimer is paramount: Nothing in this article should be construed as advice on dietary or supplemental modalities. You should consult your physician or a trusted health care provider for your specific needs. In the interest of stimulating a great conversation between you and your health care provider the words that follow should be your guide.

The miracle of Coenzyme Q10 (CoQ10)

One of the main issues surrounding statin drugs is how it inhibits the production of a key enzyme known as CoQ10. Devastating adverse health effects have been associated with CoQ10 deficiencies and has been recognized by some parts of the medical community in the U.S. and more widely in Europe and the Far East. Many people are familiar with the term “CoQ10” but do not have a firm grasp of what it is and how vital it is to our hearts so let’s discuss it.  

CoQ10 is a powerful vitamin-like substance produced by virtually every cell in the body. It has many functions that prove to be vitally important to the body. One of those functions is converting our food into fuel for our cells to use. When we eat good, wholesome foods and CoQ10 is present in the cells in adequate supplies our energy levels rise. The science of the process in which CoQ10 does its work is actually intriguing but we will skip the detailed lesson and just say without it we would have a hard time getting much of anything done. Because the heart is such a dense muscle that is always active it is one of the top CoQ10 producers in the body and rightfully so. Beating on average 2.5 billion times during a person’s life the heart requires a wealth of energy. Statins interfere with the production of some enzymes including CoQ10 robbing the heart of significant amounts of energy. To add insult to injury as we age we tend to produce less and less of this powerful enzyme naturally setting us up for exponential energy lose and poor cardiovascular production.

Another function of this miracle enzyme is blood pressure modification. It has proven itself to be an awesome way to reduce blood pressure without harmful side effects. A meta-analysis of clinical trials conducted in 2007 by F.L. Rosenfeldt et al (Coenzyme Q10 in the treatment of hypertension…) found overwhelming, across the board evidence that significant reductions in blood pressure took place among test subjects taking the supplement when compared to the control group (who did not take CoQ10 at all). Since 1974 doctors in Japan have prescribed CoQ10 to patients who experience congenital heart failure. Further studies in the U.S. showed a marked increase of heart function and vitality in people suffering from severe (class III and class IV) cardiomyopathy. These were people who were given just a year or two to live because they were that sick until CoQ10 supplementation began.

In addition, CoQ10 is a wonderful antioxidant. Oxidative stress, especially as it relates to LDL cholesterol, is a major cardiovascular concern. Remember that cholesterol in and of itself is not the boogey man but oxidized pattern B LDL cholesterol is. Coenzyme Q10 steps in and helps to prevent oxidation of patter B LDL helping to stop the type of cardiovascular stress that plague so many people. A healthy non-inflammation inducing eating plan along with CoQ10 supplementation can make all the difference in having excellent heart health especially if the person is experiencing poor cardiovascular health at the moment.

Where to find it

Typically CoQ10 tends to be found most prevalently in the organ meat of animals such as the kidneys, liver and heart. This is the most natural way to get it from outside your own body. The problem is enzymes tend to breakdown very readily when exposed to high heat even for short periods of time. The alternative to consuming organ meat (especially if you are vegetarian) has to be in the form of a supplement.

CoQ10 supplements are out there but it is imperative you can trust the source. There is no need to consume anything that is of low quality in the hopes that it will be beneficial. High quality CoQ10 that is readily bioavailable is a must. Seek advice from a knowledgeable source when determining what you might like to use.  

In Conclusion

There is a distinct correlation between CoQ10 deficiency and poor, sometimes fatal, heart function. So much so that the evidence of years of studies should be splattered across the headlines daily warning us about the deficiency and how to overcome it through supplementation. Medically speaking it is a very cheap and efficient way to reduce mortality and morbidity from cardiovascular issues especially in comparison to drugs and surgery that both carry ill side effects while draining personal and institutional coffers worldwide.

Originally this was supposed to be the last article in the series but there are other nutrients that should be discussed that would be of great benefit to cardiovascular health. With that thought in mind one or two additional articles may be necessary for the sake of thoroughness.


Sources: The Great Cholesterol Myth (Bowden and Sinatra)

Monday, December 23, 2013

The Story of Cholesterol: The Statin Drug Nightmare Part II

Before we delve further into the nightmare that is statin drugs I think a good dose of fairness is in order. One benefit of statin drugs is that they do tend to show antioxidative abilities, decreases blood viscosity and inflammation. These are good things indeed but the trade-offs are often stupendous and some times fatal. Also, there are better, natural ways to get anti-oxidants that will not disrupt your life.

Often people who take statin drugs to lower their cholesterol experience mild to severe forms of muscle pain, fatigue, memory loss, sexual dysfunction, weakness, and cognitive dysfunction. Why is this so? It turns out that cholesterol serves many vital functions in the body and turning off production of it can lead to many serious problems as we will discuss below.

The Heart and Energy Production

Let's get to the heart of the matter. I hope you can pardon the pun but it seems to be the best place to start when discussing just how bad statin drugs tend to be. A very significant nutrient produced by the body is an enzyme called CoQ10. The highest concentrations of CoQ10 can be found in the heart because, as the most active muscle in the body, it requires much energy and CoQ10 helps to provide it. Without it the heart would cease to function properly in a relatively short amount of time. The (cruel) irony is the very drug that is meant to protect the heart can cause it the most damage.

When discussing fatigue, which can be chronic in some statin drug users, we are really discussing energy. Once again this is where CoQ10 comes in to play. Not only is the heart served by this important enzyme but all muscles in the body. It helps the metabolic processes of every cell which in turn produces energy. Limiting or eliminating production of CoQ10 can create states of fatigue that are misery inducing and life altering while at the same time weakening the heart.

The Brain

Memory loss and the inability to think clearly (cognitive dysfunction) is one of the most frightening side effects of statin drug use. Unfortunately, it is also the most frequently reported side effect. Sometimes the dysfunction is so intense it can mimic Alzheimer disease.  How does this happen? As it turns out the brain is composed of approximately 60% cholesterol. At night, as we sleep and slumber, our bodies help to repair and restore brain function with cholesterol being one of the primary ingredients. As cholesterol levels decrease so does brain function. In addition to repairs, cholesterol is a chief component in helping neurotransmitters function properly. This was conclusively demonstrated in 2009 by a Iowa State University professor by the name of Dr. Yeon-Kyun Shin. It turns out that cholesterol influences the shape and function of certain proteins in the brain that help stimulate thinking and memory.

Sexual Dysfunction

Depending upon who you ask proper brain and heart function are neck-in-neck when it comes to everyday quality of life while sexual function has its place somewhere in there. Regardless of how important sex is to you most would agree that proper sexual function is at least a close third in the three way race with the brain and heart. Cholesterol lowering medications have wrecked many sex lives with the most pronounced (and most noticeable) effect on men. All the major sex hormones are derived from cholesterol. The very hormones that causes sex lives to thrive are reduced in number and potency when cholesterol is indiscriminately cut and slashed. The hormone that is most affected is testosterone. Testosterone is a key component for proper erectile function in men and libido support for men and women (women produce small amounts of testosterone and is vitally important to all). Not to put too fine a point on the subject but mood and performance for both men and women can be adversely affected when cholesterol levels decrease. A 2009 study titled "Statins and Erectile Dysfunction: Results of a Case/Non-case Study using the French Pharmacovigilance System Database" found that men taking Crestor were two to seven times more likely to suffer from erectile dysfunction! Low testosterone levels have also been associated with decreased life expectancy and increased risk of death from cardiovascular diseases.

A bad heart, fatigue, cloudy thinking and judgement and a sex life that is left weak and uninviting is what many people have to suffer with while on statin drugs. Unfortunately, this is not all of the side effects. The others may be less troubling than what has already been mentioned here but there is one more that rarely makes the news and it has to do with our immune systems which will be addressed in the next article.

Sources include:

The Great Cholesterol Myth (Bowden and Sinatra)