The Story of Cholesterol: Inflammation is the villain that got away

Let us, for the sake of illustration, imagine a crime scene. At this crime scene is a victim who is alive but unconscious and thus unable to speak. The paramedics are working tirelessly to tend to the fallen soul as a crowd of witnesses and on -lookers gather. When the police finally arrive they begin arresting the paramedics, witnesses and the on-lookers just for being at the scene. In the meantime the true culprit goes unnoticed and is allowed to continue to victimize others. If you are anything like me a sense of injustice swept over you as you pondered this scenario as it should but this is how we treat cholesterol. Cholesterol is often (but not always...we'll get to that) the unwitting witness or even the paramedic that gets blamed for doing something it had no part in while the true villain, inflammation, gets away Scot-free to continue its reign of terror. By the way, in the illustration the silent victim is our cardiovascular system.

Inflammation our friend, Inflammation our foe

Let's be fair about inflammation before we go much further. Inflammation is a natural and necessary bodily function. It serves as a marker so the immune system can know where the bad guys are. Without inflammation pathogens in the body could wonder freely and do massive damage. While acute inflammation is a natural and necessary process chronic inflammation is a killer. What causes chronic inflammation? A whole host of things actually like highly processed foods, simple carbs, too much protein (especially from animal sources), environmental toxins, medications, alcohol, etc., etc. Chronic inflammation is extremely damaging to the cardiovascular system and cholesterol has shouldered most of the blame for the last 40-50 years. And why not? If you were responsible for generating $31 billion a year in sales you would be the fall guy forever! In addition, chronic inflammation is a silent, painless killer much like hypertension and no amount of cholesterol lowering drugs can save you from it (this point will be further illustrated when the true nature of statin drugs are discussed).

Oxidative Stress and Free Radicals

Free radical is probably a term you are now familiar with but just in case you're not a brief description follows. When it comes to free radicals it helps to think of them as a pack of teenage boys at the mall roaming around just waiting to hit on receptive looking female that approaches. The whole while they are generally annoying not only the girls but anyone in the vicinity who may be watching. This pack of boys begin to upset the whole mall experience with anyone they come into contact with. That is a nuts and bolts metaphor for free radicals. They create massive amounts of inflammation and just mess up everything.

In the end chronic inflammation is of much more concern than cholesterol ever was generally. There is one scenario where cholesterol can be a bad actor but that occasion is almost exclusively dependent on free radicals and oxidative stress (imagine that). We will continue to move forward through the true story of cholesterol and cover statin drugs in particular and what they do us!

Are you familiar with your AGE?

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What's troubling you or a loved one these days? Is it a chronic condition like diabetes, obesity, cardiovascular disease, etc. Perhaps it's something like a lack of energy, sex drive or a zest for life. Our lives today involve so much chronic stress and inflammatory foods it is a wonder we survive at all. Our lives are not meant for us to be mere survivors and there is one thing that is for sure; surviving is not thriving. Thriving involves quality of life while surviving focuses on quantity. So what does this philosophical posturing have to do with your AGE? Well, it is your AGE that partly determines how fast you "age" and it is the speed of your aging that helps determine your quality of life.

 What are AGE's?

AGE stands for advanced glycated end-products. They form throughout our lives in varying degrees depending on our aptitude to live healthy. In a nut shell AGE's are molecular trash formed when glucose (blood sugar) molecules bond with free amino groups like proteins, lipids and nucleic acids that may be in the blood at the same time. These free amino groups come primarily from inflammatory foods and when they bond with glucose they change structurally and become nutritionally void and useless. Not only are they useless but they accumulate in the body where they begin to change a person from thriving to surviving (more on this in a bit).

AGE's also attach themselves to LDL cholesterol and once attached the cholesterol oxidizes making it sticky. At this point it is just a matter of time before atherosclerosis and other degenerative cardiovascular conditions begin to set in.

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Where do they accumulate? 

AGE's have the ability to disrupt the life of all people but it is especially true for those who suffer with diabetes. The reason for this is because of where AGE's tend to accumulate. Diabetics suffer from a wide range of "spin-off" ailments such as heart attacks, nephropathy (kidney disease), stroke, neuropathy, eye disease and erectile dysfunction. AGE's find their way into cardiovascular tissues, nerve endings (especially those in the extremities and penis), brain tissues, and eyes. Once there they lodge themselves into the tissues and begin producing free radicals at a rate that is 50 times higher than non-glycated proteins. These free radicals alter the natural state of healthy cells in the body rendering them non-functional or potentially malignant (cancerous). The retinopathy, nephropathy, neuropathy, and atherosclerosis are directly correlated to this free radical production free-for-all. You no longer need to wonder why these conditions affect diabetics so specifically anymore. Furthermore, the free radicals produced can cause aging related issues such as thinning and graying hair, deep wrinkles in the skin, bone mineral depletion (leading to osteoporosis), a weakened immune system due to chronic inflammation, and adrenal fatigue causing loss of energy, drive and libido. The aforementioned issues can occur in anyone just in case you were thinking this only applied to diabetics. It's one for the AGE's.

How to avoid them?

High blood sugar levels over an extended period of time leads to increased glycation (associated with AGE's). Blood sugar control through exercise and a healthy eating plan, which would include eating foods that are minimally processed and fresh with low glycemic loads, will go along way in the fight against AGE's. If you are diabetic right now do not rely solely on medication for glucose control. Your blood sugar levels may be within normal range but your AGE's may still be high do to poor eating habits.

A simple way to check your rate of AGE production is through a HbA1c blood test. Traditionally used to check blood glucose levels it is also a way to gauge you AGE.

Source: Reversing Diabetes by Don Colbert, M.D.

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